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. 2018 Aug 2;8:11588. doi: 10.1038/s41598-018-29331-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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δ-HFO PAC and θ-HFO PAC appear at different times in occipital cortex following NVP-AAM077 adminis- tration. Top left, the profile of median (n = 6) occipital PAC in the 4^th h following NVP-AAM077 injection. Top center and right, the profiles of median (n = 6) PAC for the top quartile of epochs with respect to δ-HFO and θ-HFO PAC. Bottom left, time courses of summed δ-HFO and θ-HFO PAC for 6 min periods following injection (bottom left, representative animal, circles indicate 6 min periods in the top quartile). Bottom right, the correlation between δ-HFO PAC and θ-HFO PAC over the 4 h following injection for all animals.