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. 2018 Aug 2;8:11631. doi: 10.1038/s41598-018-30100-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of ctDNA in pretreatment plasma samples from 17 pancreatic cancer patients. The top panel summarizes the mutations detected in the 17 patients based on method (i.e., M_P/KRAS, M_P/FNA, and M_P/TR). While interrogation of KRAS hotspots (M_P/KRAS) detected ctDNA from 10 patients, analyses of variants detected from FNA samples (M_P/FNA) and broad genomic target regions (M_P/TR) detected tumor variants in 12 and 15 plasma samples, respectively. The oncoprint chart presents the M_FNA and M_P/TR at the gene level. If a variant was detected in both the M_FNA and M_P/TR, the variant also corresponded with M_P/FNA. The number of affected genes for each patient was plotted at the bottom of the chart. The number of samples that harbored a mutation in each gene is plotted on the right side of the chart. Two * and four † independent mutations in PDGFRB and ATM were detected in the P43 FNA and plasma samples, respectively.