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. 2018 Aug 2;8:11631. doi: 10.1038/s41598-018-30100-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Monitoring of ctDNA in pancreatic cancer patients undergoing therapeutic interventions. The ctDNA levels estimated by M_P/TR were plotted on the left y-axis for eight patients (a–h). The entire list of M_P/TR is summarized in Supplementary Table 6. Chemotherapeutic agents administered to each patient and therapeutic response was evaluated based on the Response Evaluation Criteria In Solid Tumors are displayed at the top of the graph. CA 19-9 level (yellow solid line) and tumor size (dark-khaki dotted line) based on CT images were plotted against the right y-axis. CCRT, concurrent chemoradiation therapy; CR, complete response; DOD, dead of disease; Dx, diagnosis; E, erlotinib; GEM, gemcitabine; FU, fluorouracil; P, cisplatin; Met, metastasis; ND, not detected; Op, operation; PD, progressive disease; PR, partial response; SD, stable disease.