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. 2018 Aug 2;4:22. doi: 10.1038/s41523-018-0075-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Prevalence of cfDNA ESR1 and PIK3CA mutations in patients with metastatic breast cancer. a The sensitivity and specificity of mutation detection in cfDNA compared to paired metastatic tissue samples. b REMARK diagram. c Prevalence of ESR1 mutations in cfDNA among ER + /HER2-metastatic patients. d Prevalence of PIK3CA mutations in cfDNA among ER + /HER2- metastatic patients