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. 2018 Aug 2;4:22. doi: 10.1038/s41523-018-0075-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Associations between clinical features and ESR1 mutations. a The distribution of the patients based on number of metastatic sites for all 113 ER + /HER2-patients. b Associations between the number of metastatic sites and the prevalence of ESR1 or PIK3CA mutations. c Interval time from diagnosis of primary disease and distant recurrence in patients with and without ESR1 mutations and in patients with and without PIK3CA mutations. Center line is median, box limits are the upper and lower quartiles, whiskers are the 1.5 x inter-quartiles and the points are the outliers. d Interval time from diagnosis of distant recurrence to blood draw in patients with and without ESR1 mutations and in patients with and without PIK3CA mutations. Center line is median, box limits are the upper and lower quartiles, whiskers are the 1.5 x inter-quartiles and the points are the outliers. e Associations between aromatase inhibitor (AI) treatment and the prevalence of ESR1 and PIK3CA mutations. f Associations between fulvestrant treatment and the prevalence of ESR1 and PIK3CA mutations