Table 3.
Univariate and multivariate regression analysis of relationships between lymph node metastasis and clinicopathological factors, subgroup classification
| a. | b. | |||||||
|---|---|---|---|---|---|---|---|---|
| Variables | Univariate regression | Multivariate regression | ||||||
| OR | 95% CI | P value | OR | 95% CI | P value | |||
| Sex | Men vs Women | 1.341 | 0.5657-3.1784 | 0.5052 | 2.9363 | 0.8322-10.3605 | 0.094 | |
| Age (year) | 1.0547 | 1.0095-1.1019 | 0.0136 | 1.042 | 0.9807-1.1072 | 0.0857 | ||
| Size (mm) | 1.0147 | 0.9827-1.0564 | 0.3954 | 1.0082 | 1.0654-0.9918 | 0.1769 | ||
| Site | Right vs Left | 3.7959 | 1.3130-13.8392 | 0.0123 | 4.4896 | 0.7479-26.9502 | 0.1005 | |
| Microscopic type | I vs IIc | 0.1041 | 0.01239-0.8743 | 0.0372 | 0.2629 | 0.01839-3.7578 | 0.3249 | |
| IIc vs IIa+IIc | 8.5000 | 0.9708-72.4243 | 0.0532 | 3.3592 | 0.2519-44.7973 | 0.3593 | ||
| Histologic type | WDA vs MDA | 3.000 | 0.9357-9.6181 | 0.0016 | 5.3146 | 0.8776-32.1840 | 0.0691 | |
| pSM depth | pSM1 vs pSM2 | 2.589 | 0.4318-49.5508 | 0.3342 | 1.9859 | 0.1449-27.2242 | 0.6075 | |
| Lymph vessel invasion | Low vs High | 4.680 | 0.73954-29.6163 | 0.1011 | 2.2791 | 0.1327-39.1316 | 0.5701 | |
| Venous invasion | Low vs High | 2.280 | 0.47736-10.8900 | 0.3016 | 1.779 | 0.0233-13.5495 | 0.7227 | |
| Tumor budding | Grade 1 vs 2 | 1.4444 | 0.3348-9,9812 | 0.6453 | 7.4263 | 0.4455-123.7920 | 0.1625 | |
| Subgroup | Subgroup 1 vs 2 | 6.000 | 1.1717-30.7246 | 0.0315 | 4.7729 | 0.4148-54.9239 | 0.2099 | |
| Subgroup 3 vs 2 | 4.3125 | 1.1644-15.9717 | 0.0287 | 5.9167 | 0.8423-41.5633 | 0.0739 | ||
| Subgroup 4 vs 2 | 7.3125 | 2.0273-26.3760 | 0.0024 | 15.2232 | 2.2060-105.0544 | 0.0057 | ||
Macroscopic type: I, protruded type; IIa, flat elevated type; IIc, flat depressed type; LST, laterally spreading tumor; WDA, well-differentiated adenocarcinoma; MDA, moderately differentiated adenocarcinoma; PAP, papillary adenocarcinoma; POR, poorly differentiated adenocarcinoma.