Table 5.
Univariate and multivariate regression analysis of the relationships between lymph node metastasis and clinicopathological factors, expression of CAFs and EMT markers
| a. | b. | |||||||
|---|---|---|---|---|---|---|---|---|
| Variables | Univariate regression | Multivariate regression | ||||||
| OR | 95% CI | P value | OR | 95% CI | P value | |||
| Sex | Men vs Women | 1.341 | 0.5657-3.1784 | 0.5052 | 3.9628 | 0.6684-23.4957 | 0.1060 | |
| Age (year) | 1.0547 | 1.0095-1.1019 | 0.0136 | 1.0830 | 0.8333-1.0085 | 0.0774 | ||
| Size (mm) | 1.0147 | 0.9827-1.0564 | 0.3954 | 1.0223 | 0.9078-1.0566 | 0.5433 | ||
| Site | Right vs Left | 3.7959 | 1.3130-13.8392 | 0.0123 | 4.4896 | 0.7479-26.9502 | 0.1005 | |
| Microscopic type | I vs IIc | 0.1041 | 0.01239-0.8743 | 0.0372 | 0.1035 | 0.2066-452.02 | 0.2476 | |
| IIc vs IIa+IIc | 8.5000 | 0.9708-74.4243 | 0.0532 | 0.09135 | 0.0018-4.6766 | 0.2334 | ||
| Histologic type | WDA vs MDA | 3.000 | 0.9357-9.6181 | 0.0016 | 50.9464 | 1.7405-1491.2263 | 0.0225 | |
| pSM depth | pSM1 vs pSM2 | 2.589 | 0.4318-49.5508 | 0.3342 | 22.8022 | 0.4064-1279.43 | 0.1281 | |
| Lymph vessel invasion | Low vs High | 4.680 | 0.73954-29.6163 | 0.1011 | 6.9505 | 0.0023-8.8773 | 0.3566 | |
| Venous invasion | Low vs High | 2.280 | 0.47736-10.8900 | 0.3016 | 2.6893 | 0.0062-22.3959 | 0.6361 | |
| Tumor budding | Grade 1 vs 2 | 1.4444 | 0.3348-9.9812 | 0.6453 | 31.7338 | 0.0011-0.9364 | 0.0457 (CI: -7.5030 - -0.4963)* |
|
| αSMA | 0.6895 | 0.16282-12.9186 | 0.7334 | 1.2396 | 0.3130-2.0184 | 0.6432 | ||
| CD10 | 1.2747 | 1.05536-1.5607 | 0.0120 | 1.4922 | 1.10196-2.3862 | 0.0604 | ||
| Podoplanin | 0.1077 | 1.2364-69.7862 | 0.0181 | 1.4169 | 0.8990-2.4065 | 0.1563 | ||
| FSP1 | 1.0127 | 0.8635-1.1934 | 0.8773 | 1.2247 | 0.8635-1.7818 | 0.2635 | ||
| AEBP1 | 0.9467 | 0.76339-1.1961 | 0.6301 | 0.7447 | 0.4821-1.0967 | 0.1467 | ||
| TWIST1t | 1.4703 | 0.4556-5.1679 | 0.5255 | 1.0073 | 0.7413-1.3684 | 0.962 | ||
| ZEB1 | 0.0809 | 0.6266-1.043821 | 0.1051 | 5.8386 | 0.0455-0.4342 | 0.0016 (CI: -3.0910 - -0.8342)* |
||
Macroscopic type: I, protruded type; IIa, flat elevated type; IIc, flat depressed type; OR, odds ratio; WDA, well-differentiated adenocarcinoma; MDA, moderately differentiated adenocarcinoma; CI, confidence interval; *, not significant.