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. 2018 Jun 23;9(15):2702–2712. doi: 10.7150/jca.25646

Table 5.

Univariate and multivariate regression analysis of the relationships between lymph node metastasis and clinicopathological factors, expression of CAFs and EMT markers

a. b.
Variables Univariate regression Multivariate regression
OR 95% CI P value OR 95% CI P value
Sex Men vs Women 1.341 0.5657-3.1784 0.5052 3.9628 0.6684-23.4957 0.1060
Age (year) 1.0547 1.0095-1.1019 0.0136 1.0830 0.8333-1.0085 0.0774
Size (mm) 1.0147 0.9827-1.0564 0.3954 1.0223 0.9078-1.0566 0.5433
Site Right vs Left 3.7959 1.3130-13.8392 0.0123 4.4896 0.7479-26.9502 0.1005
Microscopic type I vs IIc 0.1041 0.01239-0.8743 0.0372 0.1035 0.2066-452.02 0.2476
IIc vs IIa+IIc 8.5000 0.9708-74.4243 0.0532 0.09135 0.0018-4.6766 0.2334
Histologic type WDA vs MDA 3.000 0.9357-9.6181 0.0016 50.9464 1.7405-1491.2263 0.0225
pSM depth pSM1 vs pSM2 2.589 0.4318-49.5508 0.3342 22.8022 0.4064-1279.43 0.1281
Lymph vessel invasion Low vs High 4.680 0.73954-29.6163 0.1011 6.9505 0.0023-8.8773 0.3566
Venous invasion Low vs High 2.280 0.47736-10.8900 0.3016 2.6893 0.0062-22.3959 0.6361
Tumor budding Grade 1 vs 2 1.4444 0.3348-9.9812 0.6453 31.7338 0.0011-0.9364 0.0457
(CI: -7.5030 - -0.4963)*
αSMA 0.6895 0.16282-12.9186 0.7334 1.2396 0.3130-2.0184 0.6432
CD10 1.2747 1.05536-1.5607 0.0120 1.4922 1.10196-2.3862 0.0604
Podoplanin 0.1077 1.2364-69.7862 0.0181 1.4169 0.8990-2.4065 0.1563
FSP1 1.0127 0.8635-1.1934 0.8773 1.2247 0.8635-1.7818 0.2635
AEBP1 0.9467 0.76339-1.1961 0.6301 0.7447 0.4821-1.0967 0.1467
TWIST1t 1.4703 0.4556-5.1679 0.5255 1.0073 0.7413-1.3684 0.962
ZEB1 0.0809 0.6266-1.043821 0.1051 5.8386 0.0455-0.4342 0.0016
(CI: -3.0910 - -0.8342)*

Macroscopic type: I, protruded type; IIa, flat elevated type; IIc, flat depressed type; OR, odds ratio; WDA, well-differentiated adenocarcinoma; MDA, moderately differentiated adenocarcinoma; CI, confidence interval; *, not significant.