Table 2.
Association between P16/B7-H3 expression and clinicopathological factors.
| Variables | No. | Expression of P16 | Expression of B7-H3 | ||||
|---|---|---|---|---|---|---|---|
| Negative | Positive | P-value | Negative | Positive | P-value | ||
| Age | 0.8978 | 0.0657 | |||||
| ≤45 | 35 | 4 | 31 | 10 | 25 | ||
| >45 | 25 | 4 | 21 | 13 | 12 | ||
| Histology | 0.1093 | 0.2629 | |||||
| SCC | 52 | 5 | 47 | 18 | 34 | ||
| Adenocarcinoma | 8 | 3 | 5 | 5 | 3 | ||
| Clinical Stage | 0.5209 | 0.8224 | |||||
| Stage I | 35 | 6 | 29 | 13 | 22 | ||
| Stage II | 25 | 2 | 23 | 10 | 15 | ||
| Differentation | 0.9392 | 0.7286 | |||||
| Low | 27 | 4 | 23 | 11 | 16 | ||
| Moderate/High | 33 | 4 | 29 | 12 | 21 | ||
| Tumor Size | 0.6580 | 0.5181 | |||||
| <4cm | 37 | 6 | 31 | 13 | 24 | ||
| ≥4cm | 23 | 2 | 21 | 10 | 13 | ||
| LNM | 0.3427 | 0.8458 | |||||
| Negative | 49 | 8 | 41 | 19 | 30 | ||
| Positive | 11 | 0 | 11 | 4 | 7 | ||
| LVSI | 0.6196 | 0.1735 | |||||
| Negative | 55 | 33 | 17 | 23 | 32 | ||
| Positive | 5 | 8 | 2 | 0 | 5 | ||
| DSI | <0.0001* | 0.0013* | |||||
| <1/2 | 16 | 8 | 8 | 12 | 4 | ||
| ≥1/2 | 44 | 0 | 44 | 11 | 33 | ||
SCC, squamous cell carcinoma; LNM, lymph node metastasis; LVSI, lymph vascular space involvement; DSI, deep stromal invasion. *Statistically significantly value.