Figure 5.

Co-treatment of Zyflamend and cisplatin had an inhibitory effect on T24R xenografts.

Notes: (A) Schematic illustration of experimental protocol described in the section “Materials and methods”. Vehicle group was given olive oil (100 μL, po daily) and PBS (100 μL, ip once weekly), Zyflamend group was given Zyflamend (1 g/kg in 100 μL olive oil, po daily), Cisplatin group was given cisplatin (5 mg/kg in 100 μL, PBS, ip, once weekly), and Combination group was given Zyflamend (1 g/kg in 100 μL olive oil, po daily) and cisplatin (5 mg/kg in 100 μL PBS, ip once weekly). Photograph (B) and tumor weight (C) of UBC xenografts with different treatments at the end of experiment. The tumor volume (D) and body weight (E) of tumor-bearing mice over time are shown. Data are presented as mean ± SE; **P<0.01; ***P<0.001.

Abbreviations: T24R, cisplatin-resistant T24 cell; po, per os; ip, intraperitoneally; UBC, urinary bladder cancer; SE, standard error; ns, non significant.