Table 1.

Effect of zyxin on different tumours.

Cancer	Zyxin effect	Possible mechanism
Melanoma	Oncogene	Directly results in cell spreading and proliferation. Could be through interaction with WT1
Hepatocellular carcinoma	Oncogene	Through binding with LASP-1 affecting actin filament dynamics and resulting in tumour spread.
Breast cancer	Oncogene	Directly results in cell spreading and proliferation. Through binding with LASP-1.
Clear cell Renal cell carcinoma	Oncogene	Directly results in cell spreading and proliferation. Through binding with LASP-1.
Ovarian cancer	Oncogene	Through binding with LASP-1.
Non Hodgkin lymphoma	Oncogene	Directly results in cell spreading and proliferation.
Glioma	Oncogene	Directly results in cell spreading and proliferation.
Penile cancer	Oncogene	Indirect effect through binding with HPV6 E6 protein, enhancing wart growth and cancer development.
Cervical cancer	Oncogene	Indirect effect through binding with HPV6 E6 protein, enhancing wart growth and cancer development.
Gastric cancer	Suppressor	Through binding with CARP-1, it promotes apoptosis.
Ewing sarcoma	Suppressor	Decreases cell motility and growth, by localization in cytoplasm.
Prostate cancer	Suppressor	Through interacting with Myopodin, acting as an activator for Myopodin tumour suppressor effect.
Testicular cancer	Suppressor	Through interacting with Myopodin.
Bladder cancer	Suppressor	Through interacting with β-catenin, interfering with its pathway and suppressing tumour proliferation.