Table 4.
Diagnosis based only on endomyocardial biopsy findings
| Diagnosis | Frequency | % |
|---|---|---|
| Virus‐associated cardiomyopathya , b | 25 | 25 |
| Parvovirus B19 | 21 | 21 |
| Coxsackie virus | 2 | 2 |
| Combined B19V /coxsackie | 1 | 1 |
| Combined B19V/HHV | 1 | 1 |
| Inflammation‐associated cardiomyopathyb | 47 | 47 |
| Inflammatory cardiomyopathy, virus negative | 23 | 23 |
| Giant cell myocarditis | 1 | 1 |
| Eosinophilic myocarditis | 1 | 1 |
| Post‐inflammatory cardiomyopathyc | 22 | 22 |
| Amyloidosisb | 3 | 3 |
| Unknown causec | 25 | 25 |
| Total | 100 | 100 |
B19V, parvovirus B19; HHV, human herpes virus.
Active replication of the respective virus; compare with Figure 2 . Please note that the individual with active replication of HHV6 listed in Figure 2 had a replication of only 43 copies, considered too low to qualify for virus‐associated cardiomyopathy. The individual with active replication of Epstein–Barr virus had cardiac amyloidosis and was therefore not considered to have virus‐associated cardiomyopathy as the leading diagnosis.
In total, 30 patients had any form of active inflammation. Twenty five had inflammatory cardiomyopathy, giant cell myocarditis, or eosinophilic myocarditis; active virus replication plus inflammation was present in four of the 30 patients, filed under virus‐associated cardiomyopathy; one had amyloidosis plus inflammation, filed under amyloidosis.
No active myocardial disease, for example, virus negative, no active inflammation; sum of ‘post‐inflammatory cardiomyopathy’ and ‘unknown cause’ equals n = 47.