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Relationship between age and height at pubertal onset. Scattering chart of age and height at the onset of puberty among the subjects (boys: 22 subjects, girls: 19 subjects) who reached to puberty during GH treatment. Pubertal onset was evaluated every 3 months before approval and every 6 months during post marketing phase. -------: ± 1, ± 2, –2.5, –3 SD of standard growth curve for Japanese children, ●: baseline height SDS < –2.5 SD, ○: –2.0 SD > baseline height SDS ≥ –2.5 SD.
