Table 3.

Regions of Cortical Thinning.

Areas of cortical thinning: cortical thickness (mm)
	GTCS (N = 53)	Control (N = 530)
	Mean ± SD	Mean ± SD	P value
Lateral orbitofrontal
Left	2.53 ± 0.157	2.65 ± 0.164	<0.001*
Right	2.55 ± 0.168	2.58 ± 0.210	<0.22^
Medial orbitofrontal
Left	2.33 ± 0.156	2.40 ± 0.183	<0.002*^
Right	2.32 ± 0.181	2.38 ± 0.212	<0.03*
Frontal pole
Left	2.46 ± 0.410	2.81 ± 0.295	<0.001*
Right	2.44 ± 0.418	2.80 ± 0.278	<0.001*
Superior frontal
Left	2.62 ± 0.176	2.75 ± 0.155	<0.001*
Right	2.57 ± 0.179	2.77 ± 0.169	<0.001*
Rostral Middle frontal
Left	2.25 ± 0.139	2.35 ± 0.141	<0.001*
Right	2.19 ± 0.145	2.34 ± 0.151	<0.001*
Caudal middle frontal
Left	2.45 ± 0.161	2.54 ± 0.161	<0.001*
Right	2.44 ± 0.154	2.54 ± 0.180	<0.001*
Precentral gyrus
Left	2.50 ± 0.162	2.48 ± 0.186	<0.48
Right	2.46 ± 0.149	2.47 ± 0.194	<0.84

Mean cortical thickness values of frontal lobe ROIs in combined male and female group from 53 GTCS patients vs 530 age- and gender-matched controls. Two-sample, two-tailed t-tests assuming unequal variances. (*) indicates significant p-value. (^) indicates significant GTCS sex-related differences relative to controls; see Table 5 for details.