Figure 3.

Human cancers with downregulation of PAR1, PAR2 and PAR4 expression. A few cancers displayed significant decreases in expression of PARs based on GEPIA analysis. PAR1 showed significantly downregulation in kidney chromophobe (66 tumor, 53 normal) and kidney renal papillary cell carcinoma (286 tumor, 60 normal). PAR2 was significantly downregulated in kidney chromophobe and skin cutaneous melanoma (461 tumor, 558 normal). PAR4 was significantly downregulated in acute myeloid leukemia (173 tumor, 70 normal), lung adenocarcinoma (483 tumor, 347 normal), lung squamous cell carcinoma (486 tumor, 338 normal), testicular germ cell tumors (137 tumor, 165 normal), and thyroid carcinoma (512 tumor, 337 normal). RNA-seq data are expressed as relative gene expression using transformed log₂ (TPM+1) value (Y-axis) of tumor (red) and normal (grey) samples from different cancer types and displayed as whisker plots as shown in Figure 1. The data showing differences in PAR expression in tumor compared to normal tissue are significant based on one-way ANOVA (* p < 0.01).