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Xie model for Na/K-ATPase signaling showing Na/K-ATPase (orange proteins) serving as scaffolding protein in caveolae regulating the tyrosine kinase activity of Src. Na/K-ATPase can act as a specific receptor for CTS and as a non-specific receptor for ROS. As this signal cascade generates ROS, the Na/K-ATPase-Src cascade can serve as a feed forward amplifier for ROS. Source: Kennedy et al. (2006) [26].
