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. 2018 Jul 23;19(7):2139. doi: 10.3390/ijms19072139

Figure 3.

Figure 3

Depiction of alignment of the Na/K-ATPase alpha1 subunit with the Src Kinase domain. Further exploration defined a 20-aminoacid sequence in the N domain (part of CD3 domain) of alpha1, which binds Src’s kinase domain (NaKtide). (A) Schematic illustration of the structure of Src representing the SH3-SH2 domain, tyrosine kinase, and different GST-fusion proteins [27]. (B) Western blot analysis demonstrating the ouabain-induced release of kinase domain from the Na/K-ATPase, blotted against anti-α-1 antibody [28]. (C) Schematic structural representation of a portion of the TAT protein to form a 33 AA cell permeant peptide, pNaKtide. Source: Tian et al. (2006) and Li et al. (2009) [27,28].