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. 2018 Jul 19;19(7):2099. doi: 10.3390/ijms19072099

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Breg cells in the neonate. Breg cell frequency is increased in neonates, providing improved tolerance to allogenic antigens (i.e., after cord blood stem cell transplantation). Besides, there is a remarkable increase of IgM expression, which may be a new inhibitory mechanism of Bregs in neonates. Finally, Breg cells inhibit Th1 cell responses, which may be related to the reported low interferon (IFN)-γ production after mycobacterial challenge. M. tb: Mycobacterium tuberculosis, Th1: T helper 1.