Figure 4. Functional enrichment map of differentially expressed genes (DEG) in BM‐MSCs isolated from micro‐capillary networks.

1. Genes identified as DEG following transcriptome analysis are enriched and clustered by the gene ontology domain GO Cellular Component. Up‐ and downregulated genes in perivascular BM‐MSCs are displayed in red and blue, respectively (a list of differentially expressed genes with their corresponding Cellular Component terms is displayed in Dataset EV2).
2. Strongly represented GO Cellular Component clusters show a strong rearrangement of the ECM including the basement membrane (1, 2), the rearrangement of matrix interaction partners and receptors on the cell surface (3, 4), and of membrane ion channel complexes (5, 6).