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Schematic diagram showing the inhibitory effects of chrysin on kidney fibrosis in glucose/AGE-exposed renal mesangial cells and diabetic mice. Chrysin inhibited glomerulosclerosis and renal fibrosis through blocking AGEs-RAGE-TGF-β1 signaling in glucose-exposed kidneys. All the arrows indicate increase, activation or induction; ⊥ indicates inhibition or blockade.
