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Humanized yeast model expressing GFP-fused Aβ peptides tagged with an endoplasmatic reticulum (ER) or Golgi complex targeting sequence. Treusch and colleagues expressed Aβ42 N-terminally tagged with the Kar2 sequence, while D’Angelo and colleagues expressed Aβ42/ARC N-terminally tagged with the α prepro-leader sequence (with and without a C-terminal GFP tag). The scissors icon indicates cleavage of the respective proteins.
