Figure 1.

Effect of resveratrol and/or 5-FU on CRC cell migration induced by TNF-β or TNF-α in inflammatory microenvironment. Serum-starved HCT116 (A) and HCT116R (B) were cultured in alginate culture and treated as described in detail in “Section 2”. Invasive colonies were stained with toluidine blue and the number of emigrated spheroids was quantified after 10 days in culture. Each experiment was repeated at least three times and experimental values were compared with the control and statistically significant values with p < 0.05 were designated by an asterisk (*) and p < 0.01 were designated by two asterisks (**).