Table 4.
Sensitivity and specificity of point-of-care circulating cathodic antigen test using the Kato Katz technique and a combined gold standard in sub-populations of study participants.
| Sub-Population | Sensitivity % (95% CI) |
Specificity % (95% CI) |
Positive Predictive Values % (95% CI) |
Negative Predictive Values % (95% CI) |
Kappa Statistics |
|---|---|---|---|---|---|
| Using Kato Katz technique as a gold standard | |||||
| General population | 92.5% (89.4–94.9) |
73.3% (69.6–76.8) |
69.4% (65.2–73.3) |
93.7% (91.1–95.8) |
0.62 |
| HIV-1-seronegative | 93.8% (90.8–96.1) |
78.7% (74.9–82.3) |
76% (71.7–80.0) |
94.6% (92.0–96.6) |
0.70 |
| HIV-1-seropositive | 78.1% (60.0–90.7) |
45.9% (35.8–56.3) |
32.1% (21.9–43.6) |
86.5% (74.2–94.4) |
0.16 |
| Using combined gold standard | |||||
| In general population | 95.3% (93.4–96.9) |
100% (99.0–100.0) |
100% (99.4–100.0) |
92.5% (89.4–94.9) |
---- |
| HIV-1-seronegative | 95.7% (93.6–97.3) |
100% (98.9–100.0) |
100% (99.3–100.0) |
93.8% (90.8–96.1) |
---- |
| HIV-1-seropositive | 93.3% (86.7–97.3) |
100% (86.3–100.0) |
100% (96.3–100.0) |
78.1% (60.0–90.7) |
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