Figure 1.

Effect of α-adducin of Na⁺/K⁺-ATPase pump. The mutated form of α-adducin reduces endocytosis, leading to an over-expression of the Na⁺/K⁺ pump molecules on the basolateral membrane and to an increased sodium reabsorption. In the basal condition, the association between phosphatase A2 (PPA2) and adducin is reduced in tubular cells transfected with mutated adducin. The impairment of this cycle may represent the molecular mechanism underlying the reduced endocytosis observed in the presence of mutated adducin (figure adapted from Bianchi et al., Hypertnsion 2005) [3].