Figure 3.

Schematic representation of a possible new approach to target medulloblastoma stem cells (MBSCs)s and MB. Medulloblastoma has an intracellular heterogeneity, having different cell types, such as normal tumor cells and MBSCs. With the classic treatment, the elimination of normal tumor cells is achieved, and the surviving MBSCs can form the tumor again. With the proposed new approach, the MBSCs are eliminated using mTOR inhibitors and the tumor cells are eliminated using the conventional therapy, achieving total tumor regression.