Table 1.
Graphical summary of the different classification of medulloblastoma (MB) subgroups and their specifications.
| Medulloblastoma Classification System | Clinical Features | WNT | SHH | Group 3 | Group 4 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Taylor Classification | Histology | Classic, Rarely LCA | Desmoplastic/Nodular, Classic, LCA | Classic, LCA | Classic, LCA | ||||||||
| Prognosis | Very good | Infants Good; Other Intermidiate | Poor | Intermidiate | |||||||||
| Cavalli classification | α | β | α | β | γ | δ | α | β | γ | α | β | γ | |
| Metastasis | 9% | 21% | 20% | 33% | 9% | 9% | 43% | 20% | 40% | 40% | 41% | 39% | |
| Genetic alterations | Monosomy 6 | TP53 mutations | PTEN loss | TERT promoter mut | 8q loss | GFI1 and GFI1B ↑, OTX2 amp, DDX31 loss | MYC amp | MYCN and CDK amp, 8p loss, 7q gain | SNCAIP dup, i17q | CDK amp, 8p loss, 7q gain | |||
| Age | Child; Ado | Ado; Adult | Child; Ado | Infant | Infant | Adult | Infant; Child | Child; Ado | Infant; Children | Child; Ado | Child; Ado | Child; Ado | |
| Subtype histoloogy | LCA, desmoplastic | Desmoplastic | MBEN, desmoplastic | Desmoplastic | |||||||||
| Survival | 97% | 100% | 70% | 67% | 88% | 89% | 66% | 56% | 42% | 67% | 75% | 83% | |
| mTOR | mTORC1 activation | PI3K/AKT/mTOR activation | |||||||||||