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. 2018 Jul 1;11(7):1125. doi: 10.3390/ma11071125

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Schematic of a therapeutic contact lens embedded with nanoparticles composed of an outer shell (polyethylene glycol), an inner shell (poly-hydroxyethylmethacrylate) and a core (polycaprolactone); (b) Photographs of transparent nanoparticle-loaded hydrogels with different nanoparticle loadings; (c) Frequency-dependent storage moduli of control hydrogel and nanoparticle-embedded hydrogel; (d) Cumulative drug release profiles from free loteprednol etabonate (LPE)-dispersed hydrogel (●), LPE-loaded nanoparticle (▲), and LPE-loaded nanoparticle-embedded hydrogel(■). Reprinted with permission from [29].