Figure 5.

(a) Schematic of therapeutic contact lenses embedded with frontally-located implant; (b) Schematic of the fabricating process of contact lenses embedded with an HA-laden implant (Blank arrow: inner margin of the implant, white arrow: outer margin of the implant); (c) hyaluronic acid (HA) release profile in tear fluid after wearing sterilized HA implant contact lenses and soaked contact lenses on rabbit eyes; (d) changes of ocular staining levels in dry eye disease-induced rabbit eyes by benzalkonium chloride treated with HA-implant contact lenses. Reprinted with permission from [66].