Table 1.
Examples of obesity-causing manipulations and their effects on the lifespan of Drosophila. Legend: ↑ increase; ↓ decrease; - no change; nd not determined in the study.
| Obesity Type | Details | Study | Fat | Glycemia | Lifespan | Note | |
|---|---|---|---|---|---|---|---|
| Diet-induced | HSD | sucrose | [23] | ↑ | nd | ↑ | Increase in the mean lifespan, but also increase in the early mortality. |
| glucose | [21] | ↑ | ↑ | ↑ | |||
| sucrose | [31] | ↑ | ↑ | ↓ | Inhibition of the hexosamine pathway rescues lifespan. | ||
| sucrose | [19] | ↑ | ↑ | ↓ | |||
| sucrose | [71] | ↑ | nd | ↓ | Importance of the protein/carbohydrate ratio. | ||
| HFD | lard | [28] | ↑ | ↑ | ↓ | Inhibition of the immune response rescues lifespan, but not obesity. | |
| coconut oil | [29] | ↑ | nd | ↓ | Obesity and decrease in lifespan are ameliorated by endurance exercise. | ||
| coconut oil | [27] | ↑ | ↑ | ↓ | Increased levels of the total body glucose. | ||
| dietary restriction | amino acid restriction | [35] | ↑ | - | ↑ | ||
| yeast restriction | [91] | ↑ | nd | ↑ | |||
| Genetic | IIS related (reduced IIS) | Ilp2-3,5 mutants | [33] | ↑ | nd | - | |
| Ilp2 > rpr | [32] | ↑ | ↑ | ↑ | Ablation of the insulin-producing cells in the brain. | ||
| hsGAL4 > ImpL2 | [65] | ↑ | - | ↑ | Heat shock-inducible overexpression of ImpL2. | ||
| S106 > Ilp6 | [138] | ↑ | ↑ | ↑ | Overexpression of Ilp6 in the fat body. | ||
| Mth mutants | [120] | ↑ | nd | ↑ | Increased lipid reserves inferred from the starvation resistance | ||
| other | female sterile (2) adipose mutants | [103] | ↑ | nd | ↓ | Lifespan decreased in mated females. | |
| bmm mutant | [134] | ↑ | nd | ↓ | |||
| rapamycin | [34] | ↑ | nd | ↑ | Feeding with rapamycin (inhibitor of TOR). | ||