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Simplified model of symmetric and asymmetric division of LSCs. When the LSC (red) undergoes mitosis, it can be subjected to asymmetric division (A) to divide into a stem cell remaining anchored on the BM and a daughter cell detaches from the BM and migrates forward to be a TAC (B), or to asymmetric division (C) to divide into two similar daughter stem cells both remaining anchored on the BM (D).
