Table 2.
The EC50 values and 95% CI (Confidence Interval) of chemotherapy drugs in cells.
| Cells | Gemcitabine (nM) | Oxaliplatin (µM) | Fluorouracil (µM) | |||
|---|---|---|---|---|---|---|
| EC50 | 95% CI | EC50 | 95% CI | EC50 | 95% CI | |
| MIA PaCa-2-KO1 | 0.455 | 0.305–0.605 | 0.224 | 0.169–0.300 | 4.642 | 3.577–6.340 |
| MIA PaCa-2-KO2 | 0.476 | 0.322–0.665 | 0.357 | 0.210–0.661 | 4.502 | 3.720–5.525 |
| MIA PaCa-2-NC | 1.458 | 1.128–1.938 | 1.015 | 0.628–2.011 | 6.675 | 5.406–8.424 |
| MIA PaCa-2-WT | 1.546 | 1.122–2.146 | 1.171 | 0.614–4.312 | 6.777 | 5.321–9.061 |
| TB32047-KO1 | 0.240 | 0.212–0.268 | 1.661 | 1.378–2.000 | 0.962 | 0.772–1.179 |
| TB32047-KO2 | 0.274 | 0.242–0.306 | 2.084 | 1.487–2.931 | 0.828 | 0.666–1.024 |
| TB32047-NC | 0.384 | 0.345–4.266 | 5.774 | 5.309–6.281 | 1.894 | 1.713–2.092 |
| TB32047-WT | 0.413 | 0.353–0.486 | 6.178 | 5.589–6.830 | 1.947 | 1.743–2.168 |
The EC50 values of Gemcitabine and Oxaliplatin in cells with GPRC5a knockout accounted for only 30–40% of that in wild-type (WT) cells. The EC50 values of Fluorouracil in cells with GPRC5a knockout accounted for 50–75% of that in negative control (NC) and WT cells. Values keep three decimal places.