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. 2018 Jun 26;19(7):1882. doi: 10.3390/ijms19071882

Figure 1.

Figure 1

Mechanism of action of platinum salts. Platinum salts cause cancer cells’ death through two mechanisms: (A) direct covalent bonds (adducts) with DNA helix, provoking DNA breaks, and (B) the generation of reactive oxygen species (ROS) through chemical interaction with the organic components of the cell, namely proteins. Despite disturbing the metabolic equilibrium of the cell, these ROS will establish adducts with DNA, inducing DNA damage. Based on Benhar et al. [37] and Chaney et al. [38].