Figure 5.

Transcriptional regulatory subnetworks of transcription factors (hK-TFs)potentially regulating the expression of differentially interacting hnRNP K proteins (DIhKPs) and selected DIhKPs, predicted and enriched by DAVID UCSC_TFBS option. The comparison of the subnetworks reveals dynamic remodeling of the hnRNP K interactome in LNCaP, PDB, and MDB. The six enriched hK-TFs are represented in colored circles, and DIhKPs in white circles, the edges are colored according to the hK-TFs. The subnetworks were grouped by the specific comparison of proteins abundance: PDBvsLNCaP (a), MDBvsLNCaP (b), MDB and PDBvsLNCaP (c), and MDBvsPDB (d). The red arrows indicate upregulated DIhKP expression; in all other cases, DIhKPs expression is downregulated.