Figure 2.

Roles of miRNAs in TGF-β-induced epithelial–mesenchymal transition (EMT). (a) EMT circuits containing a SNAIL-miR-34 loop and ZEB1-miR-200 loop; (b) A relationship between two miRNA-transcription factor (TF) modules and three EMT states. Solid line indicates the cell state transitions among epithelial, partial EMT and mesenchymal phenotypes, which are controlled by two miRNA-TF molecular switches. Dotted line suggests the alternative transition states generated by additional molecular switches.