Table 3.
Effects of fish oil on the final body weight, relative liver weight, plasma alanine transaminase (ALT) and aspartate transaminase (AST) activities, plasma adiponectin, and hepatic lipid profiles levels in rats with chronic ethanol feeding 1,2.
| F25 | F57 | Ethanol × Fish Oil | |||
|---|---|---|---|---|---|
| Final body weight (g) | C | 425.2 ± 4.4 c | 440.2 ± 4.7 a | 437.0 ± 10.7 b | 0.74 |
| E | 392.0 ± 11.9 * | 379.3 ± 12.9 | 398.7 ± 6.0 | ||
| Relative liver weight (%) 3 | C | 2.2 ± 0 b | 2.3 ± 0 b | 2.5 ± 0 a | 0.4533 |
| E | 2.9 ± 0 * | 3.1 ± 0.1 | 3.2 ± 0.2 | ||
| Plasma ALT activity (U/L) | C | 33.7 ± 1.9 b | 39.7 ± 6.9 a,b | 41.8 ± 6.7 a | 0.1781 |
| E | 78.0 ± 15.0 * | 81.2 ± 21.4 | 66.2 ± 13.4 | ||
| Plasma AST activity (U/L) | C | 75.8 ± 5.0 b | 77.2 ± 1.2 b | 91.5 ± 3.2 a | 0.0003 |
| E | 151.5 ± 10.0 *,e | 122.0 ± 9.8 f | 131.2 ± 16.8 f | ||
| Hepatic TGs (mg TGs/g liver) | C | 9.05 ± 0.64 | 10.00 ± 0.68 | 12.26 ± 1.25 | <0.0001 |
| E | 15.51 ± 0.42 *,e | 11.61 ± 1.06 f | 8.93 ± 0.52 g | ||
| Hepatic TC (mg TC/g liver) | C | 13.10 ± 0.70 b | 14.60 ± 1.00 a,b | 17.10 ± 1.10 a | 0.8515 |
| E | 17.90 ± 0.90 * | 19.00 ± 1.30 | 20.50 ± 1.40 | ||
| Plasma adiponectin (μg/mL) | C | 12.2 ± 1.0 a | 13.9 ± 0.9 a,b | 16.5 ± 2.0 b | 0.947 |
| E | 5.1 ± 1.3 *,f | 7.4 ± 1.3 e,f | 10.3 ± 1.5 e |
1 Values are expressed as the mean ± SEM. An asterisk (*) shows a significant difference between the C and E groups (p < 0.05). Means with different superscript letters (a,b,c) shows a significant difference among the C, CF25, and CF57 groups (p < 0.05). Means with different superscript letters shows a significant difference (e,f,g) among the E, EF25, and EF57 groups (p < 0.05). 2 C, control group; CF25, control diet with fish oil substituted for 25% of olive oil; CF57, control diet with fish oil substituted for 57% of olive oil; E, ethanol group; EF25, alcohol-containing diet with fish oil substituted for 25% of olive oil; EF57, alcohol-containing diet with fish oil substituted for 57% of olive oil. 3 Relative liver weight: (liver weight/body weight) × 100%. TGs: triglycerides; TC: total cholesterol.