Table 6.
Effects of fish oil on the red blood cell membrane fatty acid composition in rats with chronic ethanol feeding 1,2.
| Fatty Acid (%) | C | CF25 | CF57 | E | EF25 | EF57 | Ethanol × Fish Oil |
|---|---|---|---|---|---|---|---|
| C16:0 | 48.87 ± 2.35 b | 54.69 ± 1.4 a | 51.75 ± 1.42 a,b | 58.68 ± 2.89 *,e | 56.83 ± 3 e | 48.39 ± 0.46 f | 0.0072 |
| C18:0 | 21.72 ± 0.44 | 21.02 ± 0.69 | 20.59 ± 0.81 | 3.73 ± 4.09 *,f | 11.12 ± 5.45 e,f | 21.71 ± 0.39 e | 0.0034 |
| C18:1 (OA, n-9) | 15.59 ± 0.53 | 14.37 ± 0.8 | 15.01 ± 0.51 | 21.41 ± 1.28 *,e | 19.19 ± 1.25 e,f | 17.23 ± 0.16 f | 0.0752 |
| C18:2 (LA, n-6) | 5.01 ± 0.39 | 4.31 ± 0.64 | 4.63 ± 0.68 | 6.03 ± 0.45 | 5.26 ± 0.62 | 4.76 ± 0.17 | 0.5821 |
| C18:3 (ALA, n-3) | 0.82 ± 0.29 | 0.76 ± 0.21 | 1.1 ± 0.23 | 1.32 ± 0.13 | 1.26 ± 0.22 | 1.15 ± 0.08 | 0.4043 |
| C20:4 (AA, n-6) | 1.67 ± 0.48 | 0.76 ± 0.21 | 1.35 ± 0.5 | 1.99 ± 0.45 e | 0.96 ± 0.17 f | 1.19 ± 0.09 f | 0.7422 |
| C20:5 (EPA, n-3) | 1.87 ± 1.34 | 0.41 ± 0.12 | 0.67 ± 0.19 | 1.04 ± 0.24 | 0.82 ± 0.3 | 0.98 ± 0.14 | 0.4347 |
| C22:5 (DPA, n-3) | 0.07 ± 0.05 | 0.11 ± 0.05 | 0.33 ± 0.14 | 0.05 ± 0.06 e,f | 0.03 ± 0.03 f | 0.17 ± 0.04 e | 0.5656 |
| C22:6 (DHA, n-3) | 1.29 ± 0.94 | 0.4 ± 0.1 | 0.73 ± 0.24 | 0.84 ± 0.09 e | 0.72 ± 0.15 e,f | 0.49 ± 0.07 f | 0.5699 |
| SFAs | 71.48 ± 2.33 | 76.95 ± 2.05 | 73.72 ± 2.29 | 64.16 ± 1.51 *,f | 69.37 ± 2.62 e | 71.71 ± 0.56 e | 0.2471 |
| MUFAs | 15.59 ± 0.53 | 14.37 ± 0.8 | 15.01 ± 0.51 | 21.41 ± 1.28 *,e | 19.19 ± 1.25 e,f | 17.23 ± 0.16 f | 0.0752 |
| PUFAs | 12.94 ± 2.66 | 8.68 ± 1.32 | 11.27 ± 2.21 | 14.44 ± 0.48 e | 11.44 ± 1.56 f | 11.06 ± 0.47 f | 0.6211 |
| Total n-3 | 4.06 ± 2.04 | 1.68 ± 0.39 | 2.83 ± 0.68 | 3.26 ± 0.45 | 2.83 ± 0.65 | 2.79 ± 0.25 | 0.539 |
| Total n-6 | 3.87 ± 0.34 | 2.69 ± 0.46 | 3.82 ± 0.87 | 5.14 ± 0.21 *,e | 3.35 ± 0.5 f | 3.51 ± 0.18 f | 0.2175 |
| n-6/n-3 | 1.46 ± 0.26 | 1.84 ± 0.31 | 1.4 ± 0.08 | 1.86 ± 0.52 | 1.26 ± 0.09 | 1.29 ± 0.08 | 0.1641 |
1 Values are expressed as the mean ± SEM. An asterisk (*) shows a significant difference between C and E groups (p < 0.05). Means with different superscript letters shows a significant difference (a,b) among C, CF25, and CF57 groups (p < 0.05). Means with different superscript letters shows a significant difference (e,f) among E, EF25, and EF57 groups (p < 0.05). 2 Crude lipids of red blood cells (RBCs) were extracted according to the method of Lee et al. [16]. Details of the fatty-acid methyl ester (FAME) analysis using a capillary gas chromatograph were same as those given in Lee et al. [16]. Details are the same as those described in Table 3. OA, oleic acid; LA, linoleic acid; ALA, alpha-linolenic acid; AA, arachidonic acid; EPA, eicosapentaenoic acid; DPA, all-cis-7,10,13,16,19-docosapentaenoic acid; DHA, docosahexaenoic acid; SFAs, saturated fatty acids; PUFAs, polyunsaturated fatty acids; MUFAs, monounsaturated fatty acids.