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The mechanism of SIRT1 inhibition of JAK2-STAT pathway. SIRT1 interacts with STAT3 and/or STAT5 deacetylating these molecules, which prevents their further phosphorylation and by this way their translocation into the nucleus. AC—acetylation marker; Box 1—proline-rich domain; FERM—N-terminal 4.1, Ezrin, Radixin, Moesin domain; JAK2—Janus kinase 2; P—phosphorylation marker; SIRT1—sirtuin 1; STAT—signal transducer and activator of transcription; red cross—inhibition.
