Figure 4.

Connected with STAT’s DNA binding inhibition mechanism of PIAS action. PIAS proteins inhibit binding of phosphorylated STATs to their DNA promoter regions. Another mechanism is associated with a sumoylation of STATs which results in inhibition of activity of these proteins. JAK2—Janus kinase 2; FERM—N-terminal 4.1, Ezrin, Radixin, Moesin domain; Box 1—proline-rich domain; P—phosphorylation marker; PIAS—protein inhibitor of activated STAT; SUMO—E3-type small ubiquitin-like modifier; STAT—signal transducers and activators of transcription; cross—inhibition.