Table 2.

Diagnostic criteria for prediabetes, impaired glucose tolerance and type 2 diabetes mellitus in children and adolescents.

			WHO Criteria	ADA Criteria
Prediabetes [25]	Glucose	Fasting plasma glucose	110–125 mg/dL (6.1–6.9 mmol/L)	100–125 mg/dL (5.6–6.9 mmol/L)
		Random Plasma Glucose	ND	Not applicable
		2-h plasma glucose (OGTT)	140–200 mg/dL (7.8–11.0 mmol/L)	140–200 mg/dL (7.8–11.0 mmol/L)
	Hemoglobin A1c		ND	5.7–6.4%
Impaired glucose tolerance [26]	Glucose	2-h plasma glucose (OGTT)	ND	140–199 mg/dL (7.8–11.0 mmol/L)
Type 2 Diabetes Mellitus [25,26]	Glucose	Fasting plasma glucose	ND	≥126 mg/dL (7.0 mmol/L)
		Random Plasma Glucose	ND	≥200 mg/dL (11.1 mmol/L)
		2-h plasma glucose (OGTT)	ND	≥200 mg/dL (11.1 mmol/L)
	Hemoglobin A1c		ND	≥6.5%

ADA: American Diabetes Association; Fasting plasma glucose: fasting for at least 8 h with no calorie intake; OGTT (2-h plasma glucose): OGTT using a load of glucose 1.75 g/kg of body weight, with a maximum of 75 g; Random plasma glucose: In patients with hyperglycemic crises or classic symptoms of hyperglycemia (e.g., polyuria, polydipsia); diabetes: In the absence of unequivocal hyperglycemia, diagnosis is confirmed if two different tests are above threshold or a single test is above threshold twice; A1c: glycosylated hemoglobin; OGTT: Oral Glucose Tolerance Test; ND: Not Declared; WHO: World Health Organization.