Figure 2.

Scheme of the involvement of one-carbon metabolism in epithelial ovarian cancer (EOC). The folic acid and choline metabolisms are deregulated in EOC due to overexpression of the alpha isoform of the folate receptor (FRα) and hyperactivation of choline kinase alpha (ChoKα), respectively. Allowing cell proliferation, chemoresistance, and survival (red rectangles), these processes contribute to EOC transformation and aggressiveness. Strategies targeting alterations in folate and choline metabolism (green rectangles) may, thus, be promising alternative approaches to treat EOC.