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. 2018 Jul 13;19(7):2045. doi: 10.3390/ijms19072045

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Truncated O-glycans affect the biological behaviour of OVCAR3 cells. (A) Flow cytometry analysis of cell proliferation (left) and apoptosis (right), quantified by BrdU and Annexin V/Pi positive cells, respectively. Significantly decreased proliferation was observed in OVCAR3 SC compared with parental OVCAR3 at 48 and 72 h after seeding. Significantly increased apoptosis was observed in OVCAR3 SC compared with parental OVCAR3 at 72 h after seeding; (B) Migratory (left) and invasive (right) properties of OVCAR3 and OVCAR3 SC, quantified following wound-healing assays and invasion through Matrigel, respectively. Significantly increased migration was observed in OVCAR3 SC compared with parental OVCAR3. No significant differences were observed in the invasive properties of OVCAR3 SC compared with parental OVCAR3. All experiments were performed in triplicate in at least two independent experiments. Values represent the mean ± SD, * p < 0.05, ** p < 0.01.