Table 4.

Change in PACs and secondary endpoints (i.e., SBP, DBP, serum glucose, serum magnesium) according to treatment group, stratified by baseline serum magnesium concentration.

Primary Outcome	Baseline Serum Magnesium Concentration				p-Interaction
	<Median		≥Median
	Intervention Effect Coefficient * (95% CI)	p-Value	Intervention Effect Coefficient * (95% CI)	p-Value
Log PAC burden	0.89 (0.51, 1.54) **	0.67	0.91 (0.61, 1.35) **	0.64	0.88
Serum magnesium, mEq/L	0.05 (0, 0.10)	0.04	0.12 (0.04,0.20)	0.004	0.24
Serum glucose, magnesium/dL	−4.7 (−13.3, 4.0)	0.29	6.0 (2.0, 10.0)	0.03	0.06
Serum glucose, magnesium/dL ¥	−3.2 (−9.0, 2.6)	0.28	6.0 (2.0, 10.0)	0.03	0.01
Systolic blood pressure, mmHg	4.8 (1.0, 8.5)	0.01	3.8 (−2.5, 10.2)	0.24	0.96
Diastolic blood pressure, mmHg	5.5 (0.6, 10.4)	0.03	2.4 (−5.6, 0.8)	0.14	0.009

CI, confidence Interval; DBP, diastolic blood pressure; PAC, premature atrial contractions; and SBP, systolic blood pressure. * Adjusted for age (≥65 or <65) and baseline concentration (e.g., when change in glucose is the outcome, models were adjusted for baseline glucose). ^¥ Outlier removed. ** Ratio of geometric means.