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Proposed mechanism of action for α-amanitin/MMAE-FGF2 conjugate. After binding to the high affinity FGFRs on the cancer cell surface dual FGF2 conjugate is internalizing by endocytosis. Processing through the endosome–lysosome pathway leads to release of MMAE and α-amanitin inside the cell and next respectively inhibit tubulin polymerization and DNA transcription.
