Table S3.

Cox regression analysis of PD-L1 as potential overall survival predictor.

Variables	Univariate Cox regression analysis		Multivariate Cox regression
	RR (95% CI)	P value	RR(95% CI)	P value
Age(years)
≤60 vs. >60	1.414 (0.838 to 2.388)	0.195	NA	NA
Gender
Male vs Female	0.601 (0.350 to 1.031)	0.065	NA	NA
pathologic stage
I+ II vs III+ IV	0.398 (0.234 to 0.678)	0.001	0.628(0.340 to 1.160)	0.137
lymphatic invasion
No vs Yes	0.355 (0.209 to 0.602)	< 0.001	0.465(0.256 to 0.844)	0.012
Histological type
CMA vs CA	0.966 (0.437 to 2.132)	0.932	NA	NA
PD-L1 expression
Low vs High	0.950(0.231 to 3.910)	0.943	NA	NA
miR-191-5p expression
Low vs High	2.367 (1.112 to 5.037)	0.025	1.896(0.873 to 4.116)	0.106

RR: relative risk, CMA: Colon Mucinous Adenocarcinoma, CA: Colon Adenocarcinoma.