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Effects of a muscarinic receptor antagonist on muscarinic contraction via orthosteric sites. (A) Concentration-inhibition curves for atropine, tiotropium and glycopyrronium against MCh (10 μM); (B) Concentration-response curves for MCh (control) in the absence and presence of atropine, tiotropium and glycopyrronium (each 10 nM). MCh: methaxholine.
