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. 2018 Aug;19(8):1027–1039. doi: 10.1016/S1470-2045(18)30332-2

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© 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Total doxorubicin concentration in plasma and tumour samples analysed by high-performance liquid chromatography (HPLC)

(A) Lyso-thermosensitive liposomal doxorubicin (LTLD) plasma pharmacokinetic data by HPLC. Data for patient I.01 are omitted from the plot, because concentrations were much greater than the top standard, resulting in a ten-fold dilution step for plasma analysis subsequently being introduced to the assay. (B) Intratumoural pharmacokinetic data by HPLC. The post-LTLD values for patient I.02 and I.06, and the post-LTLD plus focused ultrasound (FUS) values for patient I.06 are worst-case estimates.