Table 3.
Summary of statistics for the post-drug thermometry analysis for all part I patients, for both raw and polynomial fitted data
| Real-time trace duration (min:s) |
Analysis of unprocessed real-time thermometry data |
Thermometry analysis of polynomial fitted real-time thermometry data |
||||||
|---|---|---|---|---|---|---|---|---|
| Temperature 39·5–47°C (min:s) | Temperature >47°C (min:s) | Mean temperature, °C (SD) | Maximum temperature, °C | Minimum temperature, °C | Mean temperature, °C (SD) | CEM43(min:s) | ||
| I.01 | 33:13 | 23:19 | 00:00 | 39·8 (0·77) | 40·4 | 37·1 | 39·7 (0·81) | 00:28 |
| I.02 | 74:34 | 27:52 | 00:00 | 39·4 (1·66) | 41·4 | 35·9 | 39·3 (1·30) | 01:42 |
| I.03 | 73:54 | 00:06 | 00:00 | 38·9 (0·37) | 39·2 | 38·0 | 38·9 (0·36) | 00:16 |
| I.04 | 65:59 | 63:14 | 00:00 | 41·5 (0·95) | 42·6 | 37·4 | 41·5 (1·07) | 13:05 |
| I.05 | 79:52 | 55:49 | 00:00 | 40·1 (1·25) | 41·1 | 37·4 | 40·0 (0·82) | 02:07 |
| I.06 | 64:11 | 35:57 | 02:00 | 40·7 (2·58) | 41·4 | 39·1 | 40·6 (0·47) | 02:52 |
Cumulative equivalent in minutes at 43°C (CEM43) has been calculated on the fitted data to better represent the average bulk temperature of the heated tumour volume and reduce thermistor artifact effects, which were especially prominent in patient I.06. Thermometry captured before or after focused ultrasound exposure has been excluded from the analysis. Polynomial fit was done with least squares fit of fourth order in MatLab.