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Schematic diagram of the anti-inflammation mechanism of BXXTR in IMQ-induced psoriasis-like skin inflammation. (a) IMQ stimulate TLR8 in macrophage and DCs thus to release IL23, TNF-α and NF-κB to induce IL-17 dependent inflammation; (b) BXXTR could inhibit the expression of TLR8, TGF-β and IL-18 thus to inhibit the activation of TLR8-IL-23-IL-17, TLR8-NF-κB, TGF-β-MAPK13-TNF-α and IL-18-IL-17 signaling pathways to inhibit apoptosis and inflammation.
