Table 3.

Association between polygenic risk scores (PRS) percentiles and ovarian cancer risk: unadjusted and adjusted by family history of ovarian cancer (FH) in first-degree or in first-degree and second-degree relatives

PRS percentile category (%)	Controls (n)	Cases (n)	OR (95% CI)
			Unadjusted by FH	Adjusted by first-degree FH	Adjusted by first-degree and second-degree FH
(a) Overall
[0,5)	72	20	0.53 (0.30 to 0.89)	0.53 (0.31 to 0.89)	0.54 (0.31 to 0.90)
[5,10)	71	17	0.46 (0.25 to 0.79)	0.46 (0.25 to 0.79)	0.46 (0.25 to 0.79)
[10,20)	143	47	0.63 (0.42 to 0.92)	0.63 (0.43 to 0.92)	0.63 (0.43 to 0.92)
[20,40)	285	137	0.92 (0.69 to 1.22)	0.92 (0.70 to 1.23)	0.93 (0.70 to 1.23)
[40,60)	286	150	1	1	1
[60,80)	285	159	1.06 (0.81 to 1.40)	1.07 (0.81 to 1.42)	1.07 (0.81 to 1.41)
[80,90)	143	102	1.36 (0.99 to 1.88)	1.37 (0.99 to 1.89)	1.37 (1.00 to 1.90)
[90,95)	71	51	1.37 (0.91 to 2.06)	1.37 (0.91 to 2.06)	1.37 (0.90 to 2.06)
[95,100]	72	67	1.77 (1.20 to 2.61)	1.79 (1.21 to 2.64)	1.78 (1.21 to 2.62)
FH				1.52 (0.94 to 2.44)	1.28 (0.88 to 1.87)
(b) Serous
[0,5)	72	12	0.51 (0.25 to 0.94)	0.51 (0.25 to 0.94)	0.51 (0.25 to 0.95)
[5,10)	71	10	0.43 (0.20 to 0.83)	0.43 (0.20 to 0.82)	0.43 (0.20 to 0.83)
[10,20)	141	33	0.71 (0.45 to 1.10)	0.72 (0.46 to 1.11)	0.72 (0.45 to 1.11)
[20,40)	287	78	0.83 (0.59 to 1.16)	0.83 (0.59 to 1.17)	0.83 (0.59 to 1.17)
[40,60)	286	94	1	1	1
[60,80)	285	102	1.09 (0.79 to 1.51)	1.09 (0.79 to 1.51)	1.09 (0.79 to 1.51)
[80,90)	143	68	1.45 (1.00 to 2.10)	1.45 (1.00 to 2.10)	1.45 (1.00 to 2.10)
[90,95)	71	41	1.76 (1.12 to 2.75)	1.77 (1.13 to 2.77)	1.77 (1.12 to 2.77)
[95,100]	72	51	2.16 (1.40 to 3.30)	2.15 (1.40 to 3.30)	2.14 (1.39 to 3.28)
FH				1.54 (0.88 to 2.63)	1.36 (0.88 to 2.08)