Table 1.
Genotype frequencies of Apa-1, Bsm-1, Fok-1, and Taq-1 in VDR gene polymorphisms in the studied groups and the association with AP.
| Genotype | AP n (%) |
Control n (%) |
OR (95% CI) AP vs. Control |
p-Value |
|---|---|---|---|---|
| Apa-1 (rs7975232) | ||||
| AA (TT) | 51 (39.5) | 30 (27) | 1.0 | |
| Aa (TG) | 51 (39.5) | 53 (48) | 1.76 (0.98–3.19) | 0.06 |
| aa (GG) | 27 (21) | 27 (25) | 1.70 (0.84–3.41) | 0.14 |
| AA vs. Aa + aa | 1.73 (1.14–2.63) | 0.009 | ||
| Bsm-1 (rs1544410) | ||||
| BB (GG) | 12 (9) | 16 (15) | 1.0 | |
| Bb (GA) | 66 (51) | 58 (53) | 0.66 (0.29–1.51) | 0.32 |
| bb (AA) | 51 (40) | 36 (33) | 0.53 (0.22–1.25) | 0.15 |
| Bb + bb vs. BB | 1.72 (0.97–3.07) | 0.06 | ||
| Fok-1 (rs2228570)FF (CC) | 51 (40) | 39 (35) | 1.0 | |
| Ff (CT) | 57 (44) | 47 (43) | 1.07 (0.61–1.90) | 0.79 |
| ff (TT) | 21 (16) | 24 (22) | 1.49 (0.73–3.07) | 0.27 |
| FF vs. Ff + ff | 1.45(0.90–2.34) | 0.12 | ||
| Taq-1 (rs731236)TT (TT) | 56 (43) | 27 (25) | 1.0 | |
| Tt (TC) | 64 (50) | 63 (57) | 2.05 (1.11–3.77) | 0.02 |
| tt (CC) | 9 (7) | 20 (18) | 4.55 (1.69–12.20) | 0.003 |
| TT vs. Tt + tt | 2.61 (1.68–4.03) | <0.0001 |
Genotype frequencies of VDR SNPs were determined in the control group, alcohol group, and patients with AP, and associations with AP.