Table 2.

LPA receptor subtypes and their biological functions.

LPAR Subtypes	Biological Functions	References
LPA1	Cell survival, proliferation, adhesion, migration, immune function, and myelination	[53]
LPA2	Similar to and complementary to LPA1-mediated effects	[33,54]
LPA3	Mainly involved in reproductive functions—fertility, implantation of the embryo	[55]
LPA4	Cell adhesion and aggregation, vascular development, regulation of osteogenesis, offset LPA1- and LPA2-mediated chemokine release	[56,57]
LPA5	Inhibits cell motility Involved in chemokine release	[48,58]
LPA6	Not fully elucidated Mutations linked to hair loss and hypotrichosis	[59,60,61]